Forming Trees with Treeformers

Popular models such as Transformers and LSTMs use tokens as its unit of information. That is, each token is encoded into a vector representation, and those vectors are used directly in a computation. However, humans frequently consider spans of tokens (i.e., phrases) instead of their constituent tokens. In this paper we introduce Treeformer, an architecture inspired by the CKY algorithm and Transformer which learns a composition operator and pooling function in order to construct hierarchical encodings for phrases and sentences. Our extensive experiments demonstrate the benefits of incorporating a hierarchical structure into the Transformer, and show significant improvements compared to a baseline Transformer in machine translation, abstractive summarization, and various natural language understanding tasks

IN VITRO EVALUATION OF ANTI-CANCER POTENTIAL OF A3 ADENOSINE RECEPTOR AGONIST ON A549 HUMAN LUNG CANCER CELL LINE

Objective: The objective of this study was to evaluate the cytotoxic potential of A3AR agonist (ABMECA) against human lung cancer cell line A549 by using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. Methods: Adenocarcinoma cell line A549 was used to assess MTT based cells viability. In vitro cytotoxic activity was evaluated for 3 different concentration of doxorubicin and A3AR by MTT cytotoxicity assay. Cytotoxicity assay carried out for 3 consecutive days that involves culturing cells into Dulbecco’s MEM medium modified with 10% FBS for 24 h then treatment with different dose of standard and test drug with incubation period of 24 h followed by treatment with MTT for estimation of cytotoxicity and finally, optical density (OD) was measured at 570-630 nm. Results: Different concentration of doxorubicin (1, 5, 10 µM) and ABMECA (10-6M, 10-5M and 10-4M) shown dose-dependent cytotoxicity. There was a significant decrease (p<0.05) in cell viability in both doxorubicin and ABMECA concentration in a dose-dependent manner. This study may guide further for in vivo evaluation of test drug in the lung cancer model. Conclusion: A3 Adenosine Receptor agonist could be potential moiety for the treatment of lung cancer and it would require in vivo study for further research

DRUG UTILIZATION PATTERN AND PHARMACOECONOMIC ANALYSIS OF ANTIHYPERTENSIVE DRUGS PRESCRIBED IN SECONDARY CARE HOSPITAL IN GUJARAT, INDIA

ABSTRACTObjective: Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if notdetected early and treated appropriately. A large number of antihypertensive drugs alone or in various combinations are available, and physiciansneed to choose most appropriate drug for a particular patient. Pharmacoeconomic and drug utilization studies at regular intervals help physicians toprescribed rational drugs with high efficacy along with minimal cost.Methods: The prospective observational study was conducted at Seth H. J. Mahagujarat Hospital from July to December 2013. 250 hypertensivepatients, attending medicine outpatient department were included for drug utilization study and 100 hypertensive patients, attending in patientsdepartment were included for pharmacoeconomics analysis during the study period.Result: The most frequently prescribed antihypertensive drug as monotherapy, as combination therapy and in fixed dose combinations was calciumchannel blocker (Amlodipine). Generic drugs showed same efficacy as brand drug, but both drugs were significantly differed in the prize. Among 100inpatients admitted for the hypertensive condition in general ward total of direct medical cost was 65.19% and total of indirect medical cost was34.81%. β-blocker and diuretics were the most effective therapy which is followed by the clonidine, envas (Enalapril), and then, amlodipine.Conclusion: We concluded from this study that use of β-blockers and diuretics were most cost-effective for the hypertensive patients in this study.Keywords: Antihypertensive drugs, Drug utilization study, Pharmacoeconomics analysis.Â

Coronary artery disease prescribing pattern and risk factor assessment in the patients undergoing angioplasty

Background: Coronary artery disease is caused by an obstruction in vascular supply to the heart. Angioplasty is a frequently used intervention for the management of CAD patients. Supportive and preventive therapies are additionally provided to these patients. Objective of current study was to assess the associated risk factors as well as prescribing trends in CAD patients.Methods: A prospective study was conducted in 88 patients undergoing coronary angioplasty. Patients were assessed for risk factors of CAD. Medication history of patients was recorded in case record form for analysis of prescribing trend and its rationality. Data were statistically analyzed using prism software.Results: In present study most of the CAD patients were male (80.68%) and mean age of patient was 59.19 years. Majority of patients (39.77%) were in age range of 61-70 years. Most common associated conditions at admission were hypertension and diabetes. In this study, BMI, stress, lack of exercise, hypertension, diabetes, family history of CVD were risk factors of CAD and significant correlation observed with risk factors and coronary artery disease. (p<0.05) Frequently prescribed drugs were antiplatelet, antibiotics, antihypertensive, antiulcer, antihyperlipidemic, antidiabetic agents. In 19.31% cases, drug interaction was detected out of which two cases recorded severe. Medical stents coated with everolimus, sirolimus were also prescribed.Conclusions: It was concluded that history of cardiovascular disease, hypertension, diabetes are major risk factors of CAD. Certain level of irrationality in the prescribing trend was observed. Proper patient counselling and care can help in preventing CAD and reduces health burden

Iridocorneal endothelial syndrome: iris naevus (Cogan-Reese) syndrome. A case report

The purpose is to present a case of iridocorneal endothelium Syndrome with glaucoma and discuss clinical presentation and management strategies. A 45 year old female presented with redness, pain and diminision of vision in left eye. The patient was completely evaluated for the complaints. Slit lamp biomicroscopy revealed semidilated pupil not reacting to light and variation in iris colour pattern. Intraocular pressure was 14mmHg in the right eye and 46mmHg in the left eye. Gonioscopy of the left eye revealed broad based peripheral anterior synechiae. The optic disc of the left eye had a cup of 0.7. Specular microscopy of the left eye showed pleomorphism and polymegathism with multiple guttatae. This case reports the importance of specular microscopy in the evaluation of ICE syndrome and to plan the appropriate management strategies. We performed a trabeculectomy surgery for this patient with a well-functioning bleb to reduce the intraocular pressures following failure of topical anti-glaucoma medications

Comparative study of sonosalpingography versus hysterosalpingography for tubal patency test

Background: Various tubal pathologies accounts for 10% aetiological factors in infertility couples. Easy availability and accessibility of ultrasonography definitely can prove superior to conventional method of diagnosis of tubal patency in such patient. Aims and objectives of the study were to test the sensitivity and specificity of sonosalpingography (SSG) for tubal patency test in cases of infertility patients attending to our OPD and to compare the result of sonosalpingography v/s HSG.Methods: In a non randomised prospective control trial of 50 women complaining of infertility, suspected tubal pathologies underwent various radiological modalities. Sonosalpingography and hysterosalpingography was performed in all cases.Results: By using binomial proportion test there is no significant difference between results of SSG compare to HSG. Acceptability was 100% in SSG compared to 96% in HSG.Conclusions: Various modalities are suggested to evaluate tubal patency test in infertile women. Among those laparoscopic chromopertubation is gold standard method, but for initial workup as cost effectiveness acceptability, accessibility is concerned SSG is always superior to HSG

Reducing Power Consumption in Sensor Network Using Sensor MAC Protocol

© ASEE 2009Wireless sensor networks are quickly gaining popularity due to the fact that they are potentially low cost solutions to a variety of real world challenges. Their low cost provides a means to deploy large sensor arrays in a variety of conditions capable of performing both military and civilian tasks. This technology consists of some of the electronic devices which work to run this system successfully and all those have some amount of power consumptions. It is a challenge of maximizing the processing capabilities and energy reserves of Wireless sensor nodes while also securing them against attackers. So, finally we have decided to work on finding out the optimum solution for controlling the power and saving energy. There are number of ways to reduce power consumption and MAC protocol is one of them. So we describe Sensor MAC protocol to reduce power consumption

Investigations into tensile strength of banana fibre reinforced hybrid polymer matrix composites

Natural fibres, such as banana, coir, jute and gongura have been proved to be effective reinforcements in polymer matrix composites. This work aims to design and fabricate the banana fibre reinforced hybrid polymer matrix composites. The authors developed a hybrid polymer by blending natural and synthetic resins. The tensile behavior of fabricated composites is studied. The influences of natural resin and alkaline treatment of fibre on tensile strength are investigated. ANOVA technique is used to find the regression equations for ultimate tensile strength

Molecular modeling and ADMET predictions of flavonoids as prospective aromatase inhibitors

192-200With the advent of a myriad of treatment possibilities for breast cancer, enzyme inhibition turns out to be the prevailing strategy for inhibiting estrogen biosynthesis. Aromatization of ring A of androstenedione, testosterone and 16-hydroxytestosterone results in increased estrogen level, which embraces the risk for breast cancer. In this present research, we have targeted human placental aromatase complexed with HDDG046 (PDB ID: 4GL7) for its inhibition by several inhibitors of flavonoid derivatives and further screening those molecules for ADMET properties for assessing its credibility for acceptance in successive steps of drug discovery. Novel flavonoid derivative molecules have been designed using Maestro 10.4, based on the literature review. Further, their molecular modeling studies have been performed against the imported target PDB ID: 4GL7 using the GLIDE platform and have been subjected to ADMET assessment using the QikProp and pkCSM program. From all the series exposed to molecular modeling; 2K, 4K, 6K, 8W and 10K molecules have been subjected to ADMET study based on their interaction profile. Successively screening of these molecules led to selection of 8W molecule for further validation by pkCSM. The results obtained have been compared with the reported molecule HDDG046 which presents substantially positive outcomes for 8W in terms of CaCo2 permeability, water solubility, P- glycoprotein; hERG I, II and CYP interactions, hepatotoxicity, LD50 value and so forth. Juxtaposing the results of all the designed molecules under study, we have established that these prospective molecules especially 8W of flavonoid derivatives have the potency to inhibit the target under study, which can be useful in the treatment of breast cancer. This has been estimated based on the in silico approaches performed using Molecular Modeling which utilizes the integral function of Molecular Mechanics and Quantum Mechanics. In addition, the ADMET predictions validate their integrity for being the lead molecules in drug discovery stages in the near future

Test Targets 3.0: A Collaborative effort exploring the use of scientific methods for color imaging and process control

Test Targets 3.0 focuses on the integration and analysis of a number of input devices, color image renderings with the use of a robust CTP system and a full-fledged web offset press … The first section is a collection of test forms … The second section is a compilation of color management practices by the class. – p. v